Proteomics, Glycomics, and Glycoproteomics of Matrisome Molecules
نویسندگان
چکیده
منابع مشابه
Glycobiomarkers by glycoproteomics and glycan profiling (glycomics): emergence of functionality.
Glycans stand out from all classes of biomolecules because of their unsurpassed structural complexity. This is generated by variability in anomeric status of the glycosidic bond and its linkage points, ring size, potential for branching and introduction of diverse site-specific substitutions. What poses an enormous challenge for analytical processing is, at the same time, the basis for the fing...
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The ‘‘Integrated Database Project’’ was initiated to establish a publically accessible database to integrate all useful life science databases in Japan. Our JCGGDB (Japan Consortium for Glycobiology and Glycotechnology Database) was selected as a promotion program in the project, focussing on the integration of all the glycan-related databases and establishment of user-friendly search systems. ...
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There is a growing desire in the biological and clinical sciences to integrate and correlate multiple classes of biomolecules to unravel biology, define pathways, improve treatment, understand disease, and aid biomarker discovery. N-linked glycosylation is one of the most important and robust post-translational modifications on proteins and regulates critical cell functions such as signaling, a...
متن کاملMass spectrometry based glycoproteomics--from a proteomics perspective.
Glycosylation is one of the most important and common forms of protein post-translational modification that is involved in many physiological functions and biological pathways. Altered glycosylation has been associated with a variety of diseases, including cancer, inflammatory and degenerative diseases. Glycoproteins are becoming important targets for the development of biomarkers for disease d...
متن کاملLabel-free Quantitative Proteomics and N-Glycoproteomics Analysis of KRAS-activated Human Bronchial Epithelial Cells*□S
Mutational activation of KRAS promotes various malignancies, including lung adenocarcinoma. Knowledge of the molecular targets mediating the downstream effects of activated KRAS is limited. Here, we provide the KRAS target proteins and N-glycoproteins using human bronchial epithelial cells with and without the expression of activated KRAS (KRAS). Using an OFFGEL peptide fractionation and hydraz...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2019
ISSN: 1535-9476
DOI: 10.1074/mcp.r119.001543